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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of design which include the recruitment process and consent, adhering and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographical regions. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity, and it also helps reduce the chance of bias in the results. However, too much heterogeneity can cause issues with the design of the trial.
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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policymakers and practitioners to inform their decisions. They are also a good way to identify the causal relationship between an intervention and its outcomes. However, they shouldn't be used in lieu for explanatory studies.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. 프라그마틱 슬롯 무료 and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the features of a practical trial which includes recruitment, design and delivery of the intervention, and follow-up.
There is a positive trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatics. However, it is important to remember that the majority of these studies were conducted in primary care settings.